ATILA BIOSYSTEM'S SOLUTION

Digital PCR Lung Cancer Mutation Screening Kit is designed to identify possible 99 mutation sites in two wells in a rapid and cost-effective manner, including EGFR, KRAS, BRAF, HER2, and MET gene mutation groups. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

• Superior performance: allows quantification and screening for multiple mutations highly related to lung cancer in two wells
• High sensitivity: provides sensitive and precise detection

Digital PCR CRC mutation screening kit identifies 136 possible mutation sites in four wells in a rapid and cost-effective manner, including KRAS, NRAS, PIK3CA, and BRAF gene mutation groups. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

• Superior performance: allows quantification and screening for multiple mutations highly related to lung cancer in two wells
• High sensitivity: provides sensitive and precise detection down to 0.2% in a sin

RET/MET Digital PCR Multiplex Mutation Screening Kit identifies possible 11 mutation sites in a single well in a rapid and cost-effective manner. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

• Superior performance: allows quantification and screening for multiple RET/MET 11 mutations in a single well
• High sensitivity: provides sensitive and precise detection down to 0.2% in a single well
• Simple workflow: allows screening of multiple sample

BRAF gene mutation associated with human cancers have been identified. The frequency of BRAF mutations varies widely in human cancers, from more than 80% in melanomas and nevi, to as little as 0~18% in other tumors, such as 1~3% in lung cancers and 5% in colorectal cancer. This Kit identifies possible 62 mutation sites in a single well in a rapid and cost-effective manner. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

PIK3CA has been reported to be mutated frequently in human cancer, particularly in common cancer types such as breast, colorectal, endometrial and prostate. PIK3CA Digital PCR Multiplex Mutation Screening Kit identifies possible 39 mutation sites in a single well in a rapid and cost-effective manner. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

The human epidermal growth factor receptor 2 (HER2) overexpression/amplification is associated with poor survival in breast cancer patients. HER2 Digital PCR Multiplex Mutation Screening Kit identifies possible 18 mutation sites in a single well in a rapid and cost-effective manner. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

The TP53 gene contains homozygous mutations in about 50~60% of human cancers. TP53 Digital PCR Multiplex Mutation Screening Kit identifies possible 290 mutation sites in a single well in a rapid and cost-effective manner. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

NRAS activating mutations are associated with approximately 15~25% of patients with lung cancer and 20~50% of patients with colorectal cancer. NRAS Digital PCR Multiplex Mutation Screening Kit identifies possible 36 mutation sites in a single well in a rapid and cost-effective manner including NRAS exon 2, 3, and 4 mutation groups. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

KRAS activating mutations are associated to approximately 15~25% of patients with lung cancer and 20~50% of patients with colorectal cancer. KRAS Digital PCR Multiplex Mutation Screening Kit identifies possible 61 mutation sites in a single well in a rapid and cost-effective manner including KRAS exon 2, 3, and 4 mutation groups. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

EGFR Digital PCR Multiplex Mutation Screening Kit identifies possible 63 mutation sites in a single well in a rapid and cost-effective manner, including G719X, Ex19Del, S768I, Ex20Ins, T790M, L858R and L861Q mutation groups. The targets are determined by unlabeled multiplex primers and fluorescent labeled probes.

The Atila C. difficile test kit is designed for rapid qualitative detection of C. difficile DNA isolated from patient stool samples. The kit provides a PCR master mix which contains reagents and enzymes for PCR amplification; and a primer mix which are specific to the C. difficile genome. In addition, the kit provides an internal control to identify possible PCR inhibition or sample preparation failure.

The Atila M. pneumoniae test kit is designed for rapid qualitative detection of M. pneumoniae DNA from sputum, oropharyngeal or nasopharyngeal swabs. The kit provides simple method to lyse bacterial cells and to release DNA; a PCR master mix which contains reagents and enzymes for PCR amplification; and a primer mix which are specific to the M. pneumoniae genome. In addition, the kit provides an internal control to identify possible PCR inhibition or sample preparation failure.

The Atila H. influenzae test kit is designed for rapid qualitative detection of H. influenzae DNA isolated from cerebrospinal fluid or the respiratory tract. The kit provides a PCR master mix which contains reagents and enzymes for PCR amplification; and a primer mix which are specific to the H. influenzae genome. In addition, the kit provides an internal control to identify possible PCR inhibition or sample preparation failure.

The Atila L.monocytogenes test kit is designed for rapid qualitative detection of L.monocytogenes DNA isolated from food samples using a standard enrichment procedure. The kit provides a PCR master mix which contains reagents and enzymes for PCR amplification; and a primer mix which are specific to the L.monocytogenes genome. In addition, the kit provides an internal control to identify possible PCR inhibition or sample preparation failure.

The Atila Salmonella test kit is designed for rapid qualitative detection of Salmonella DNA from clinical specimen, food sample, or environmental samples. The kit provides a PCR master mix which contains reagents and enzymes for PCR amplification; and a primer mix which are specific to the Salmonella genome. In addition, the kit provides an internal control to identify possible PCR inhibition or sample preparation failure.

The Atila S. aureus test kit is designed for rapid qualitative detection of S. aureus DNA from clinical specimen, food sample, or environmental samples. The kit provides a PCR master mix which contains reagents and enzymes for PCR amplification; and a primer mix which are specific to the S. aureus genome. In addition, the kit provides an internal control to identify possible PCR inhibition or sample preparation failure.

The Atila S. pneumoniae test kit is designed for rapid qualitative detection of S. pneumoniae DNA isolated from nasopharyngeal swabs or patient plasma samples. The kit provides a PCR master mix which contains reagents and enzymes for PCR amplification; and a primer mix which are specific to the S. pneumoniae genome. In addition, the kit provides an internal control to identify possible PCR inhibition or sample preparation failure.